Cst fam134b
WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, FAM134B Antibody (CST #61011) is … WebJun 3, 2015 · ER-bound FAM134B interacts with a protein called LC3 in phagophores through an LIR domain, leading to engulfment of ER fragments by autophagosomes. Mochida et al . 2 report that Atg39 and Atg40 ...
Cst fam134b
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WebFAM134B overexpression also ameliorated the AE-induced ultrastructural damage in neuronal mitochondria, decrease in mitochondrial membrane potential (mMP), cytochrome c (CytC) release and caspase-3 activation, while FAM134B downregulation induced the … WebJun 15, 2024 · FAM134B is a member of the reticulon-homology-domain-containing FAM134 family and is mainly localized to the edges of the ER sheets. FAM134B binds MAP1LC3B via its LC3 interacting region (LIR) and at the same time to fragmented ER sheets and coalesces them into vesicles, which are subsequently degraded by lysosomes.
WebNational Center for Biotechnology Information WebJul 8, 2024 · The endoplasmic reticulum (ER) autophagy receptor FAM134B contains an LIR motif that can bind to Atg8s, but whether it can differentially bind to the two …
WebCommunity School 134 is a NYC DOE public school in District 12, Bronx. WebOct 13, 2015 · Mutant FAM134B proteins that cause sensory neuropathy in humans (HSAN2B; 613115) are unable to act as ER-phagy receptors. Consistently, disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death, and leads to degeneration of sensory neurons.
WebDec 16, 2024 · The Fam134b gene, located on chromosome 5p15.1, was first identified as a regulator of the malignant phenotype and a downstream molecule of δ-catenin in esophageal squamous cell carcinoma (Tang et al., 2007). However, in colon cancer, FAM134B inhibits the migration of tumor cells (Kasem et al., 2014a, b).
WebJun 3, 2015 · These data demonstrate that FAM134B is an ER-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (ER-phagy). Notably, this … chin stinksWebFAM134B (E8Y9R) Rabbit mAb Cell Signaling Technology Monoclonal Antibody for studying FAM134B. Validated for WB, IP, IF. Highly specific and rigorously validated in-house, FAM134B (E8Y9R) Rabbit Monoclonal Antibody (CST #83414) is ready to ship. Go to your regional site? Would you like to visit your country specific website? YESNO chin strap 302425WebFAM134B contains a conserved LC3 interacting domain (LIR) that facilitates binding to LC3 and GABARAP family members and targets impaired ER to the autophagosome for degradation by ER-phagy (2). ... Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products ... granny suites for sale in kitchener waterlooWebDec 14, 2024 · FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but … chin strap 1012911WebDec 2, 2024 · FAM134B was also called JK-1, encoding a newly identified Golgi resident protein. It has been reported participating in turnover of ER membranes, tumor inhibition, and lipid homeostasis 10 - 13. FAM134B might play a functional role in fat deposition, as it has been shown that FAM134B is a positive regulator of lipid deposition in preadipocytes … grannys watching youtubeWebAug 24, 2024 · Several ER surface receptors, including FAM134B, reticulon 3L (RTN3L), Sec62, and CCPG1, have been shown to contain conserved LC3-interacting regions (LIRs) that can act as specific autophagy receptors to allow portions of the larger ER network to be shunted to core autophagy pathways ( Khaminets et al., 2015; Fumagalli et al., 2016; … chin strap 302175WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and … grannys washing game