Ctcf and hbegf
WebCTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the … WebMar 15, 2012 · The genome of higher eukaryotes exhibits a patchwork of inactive and active genes. The nuclear protein CCCTC-binding factor (CTCF) when bound to insulator sequences can prevent undesirable crosstalk between active and inactive genomic regions, and it can also shield particular genes from enhancer function, a role that has many …
Ctcf and hbegf
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Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by … See more Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 and BAG1. HB-EGF biological activities with these genes influence cell … See more Recent studies indicate significant HB-EGF gene expression elevation in a number of human cancers as well as cancer-derived cell lines. Evidence indicates that HB … See more HB-EGF is the predominant growth factor in the epithelialization required for cutaneous wound healing. The mitogenic and migratory … See more • Higashiyama S, Lau K, Besner GE, et al. (1992). "Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein" See more HB-EGF binding and activation of EGF receptors plays a critical role during cardiac valve tissue development and the maintenance of normal heart function in adults. During valve tissue development the interaction of HB-EGF with EGF receptors and … See more HB-EGF is recognized as an important component for the modulation of cell activity in various biological interactions. Found widely distributed in cerebral neurons and … See more • heparin-binding EGF-like growth factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more WebMay 6, 2013 · CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies.
WebNational Center for Biotechnology Information WebHBEGF is a potent dilator of terminal mesenteric arterioles. These results demonstrate that HB-EGF-induced eNOS activation depends on p42/p44 MAPK, PI3K/Akt pathways and endogenous VEGF in HaCaT cells. At least three genes, orthologous to loci in this LD block, HBEGF, IK, and SRA1, result independently in a phenotype of myocardial contractile ...
WebJan 5, 2024 · There are at least four CTCF-enriched sites and two GR-binding sites within the ANGPTL4 locus. Among them, the major CTCF-enriched site is positioned near the ANGPTL4 enhancer that binds GR. WebMar 11, 2014 · CTCF creates boundaries between topologically associating domains in chromosomes and, within these domains, facilitates interactions between transcription …
WebMar 9, 2024 · HB-EGF promotes enteric neural stem cell proliferation and migration in a mouse model. mice in which DTR is expressed on conventional Dendritic cells display …
WebFeb 5, 2024 · CTCF physically interacts with MRE11 and CtIP and promotes CtIP recruitment to sites of DNA damage. Subsequently, CTCF facilitates DNA end resection to allow HR, in conjunction with MRE11-CtIP ... sicis telefonoWebSep 15, 2024 · The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, … sick 2022 streaming vfWebJun 28, 2024 · The regulation of genome-wide methylation by CTCF was also demonstrated in Ctcf hemizygous mice, which are an ideal model of Ctcf haploinsufficiency. Ctcf … sick 10 hoursWebOct 17, 2024 · Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of … sic jfet process flowWebCTCF ChIA-PET interactions are displayed below the ChIP-seq profiles of H3K27 acetylation (H3K27ac), YAP, TEAD4, CTCF, and cohesin (Rad21). All epigenomics data except YAP binding (derived from ... sick 2022 rotten tomatoesWebCTCFL Gene Set. CCCTC-binding factor (zinc finger protein)-like CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers … sick 2022 release dateWebSep 15, 2024 · Gained/lost CTCF binding events associate with chromatin dynamics. a, c, e, g Volcano plots showing differential chromatin interaction levels between cancer and normal cells at cancer-specific lost (blue), gained (red), and constitutive (gray) CTCF binding sites, measured by Hi-C. Each point represents the interaction changes between a CTCF … the phases of a project