Cytosolic chromatin fragments

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August undefined, 2024

WebJul 31, 2024 · We find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments in senescent cells. The activation of cGAS, in turn, triggers the … WebJan 18, 2024 · Cyclic guanosine monophosphate-adenosine monophosphate adenosine synthetase (cGAS) is a DNA sensor that detects and binds to cytosolic DNA to generate …

cGAS and cancer therapy: a double-edged sword - Nature

WebOct 1, 2024 · chromatin bridges result from errors during mitosis and consist of strands of chromatin that connect segregating chromosomes during anaphase or daughter nuclei after completion of cytokinesis. Cytosolic chromatin fragments (CCFs) CCFs locate to the cell cytosol, contain chromatin fragments encapsulated References (81) P.J. Kranzusch WebFeb 11, 2024 · Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence February 2024 Journal of Biological Chemistry 295(14):jbc.RA119.010734 incarnation\\u0027s cp

Innate immune sensing of cytosolic chromatin fragments …

WebJan 28, 2024 · Micronuclei and cytosolic chromatin fragments are common senescence-associated traits and influence the senescent state [53,[61][62] [63]. During the course of our characterization of the ... WebAug 10, 2024 · Cytosolic DNA consists of a heterogeneous population of cytosolic nucleosome-free DNA fragments, CCF and micronuclei 40, 59, 66, 67, 80, 101. … WebChromatin immunoprecipitation (ChIP)-sequencing analysis in both human and mouse cells revealed that cGAS is broadly distributed across the genome, but enriched on centromeres and pericentric heterochromatic regions, which are notoriously dense in nucleosomes [ 12. ]. in connection with kilshaw

Targeting the DNA damage response in immuno …

Interplay of cGAS with chromatin - Trends in Biochemical Sciences

WebJul 31, 2024 · We find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments in senescent cells. The activation of … WebMar 8, 2024 · After periods of progressive stress, senescent cells remodel their nuclear envelope, and this is accompanied with the repetitive release of cytosolic chromatin fragments, which present potent triggers of inflammation via cGAS (47, 48, 68). Likewise, persistent mitochondrial stress triggers cGAS-dependent cellular responses . incarnation\\u0027s cnWebOct 5, 2024 · However, the nuclear envelope dissembles at mitotic entry in vertebrate cells and the chromatin is exposed to cytosol in mitosis, which raises a question on how mitotic cells restrain innate immune responses to self-DNA. ... Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence. Nat. Cell Biol. 19, in connection to this

"WebJan 18, 2024 · Cyclic guanosine monophosphate-adenosine monophosphate adenosine synthetase (cGAS) is a DNA sensor that detects and binds to cytosolic DNA to generate cyclic GMP-AMP (cGAMP). As a second... " - Cytosolic chromatin fragments

Cytosolic chromatin fragments

cGAS is essential for cellular senescence PNAS

WebSep 12, 2024 · A pathway that senses microbial DNA also promotes senescence in cells with cytosolic chromatin fragments. The detection of cytosolic doubled-stranded … WebJan 29, 2024 · Conceptual summary of cytoplasmic chromatin fragment formation and function. Formation of CCF is linked to the DDR and …

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WebJul 31, 2024 · As an example, sensing of cytosolic chromatin fragments or free mitochondrial DNA by the cyclic GMP e AMP synthase (cGAS) following DNA damage or oxidative stress promotes the STING-dependent ... WebInnate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a …

WebApr 3, 2024 · cytosolic chromatin fragment (CCF) senescence-associated secretory phenotype (SASP) Introduction Hydrogen peroxide (H 2 O 2) or ionizing radiation can induce cellular senescence ( 1, 2 ). WebJan 23, 2024 · The cytosolic chromatin fragments activate the cGAS–STING (cyclic GMP-AMP synthase–stimulator of interferon …

WebcGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that is activated by binding to double-stranded DNA, including microbial and self-DNA (22, 23).Cytosolic DNA triggers cGAS to produce the second messenger cGAMP (), which binds and activates the adaptor protein STING (also known as MITA, MPYS, and TMEM173).STING then … WebJul 26, 2024 · Upon recognition, the cytosolic DNA sensor cyclic GMP–AMP synthase (cGAS) catalyzes the production of a second messenger 2′3′-cGAMP, which activates endoplasmic reticulum (ER)-associated stimulator of interferon (IFN) genes (STING) and ultimately leads to the induction of type I IFNs and inflammatory genes that collectively …

WebJul 31, 2024 · We find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments in senescent cells. The activation of cGAS, in turn, triggers the production of SASP factors via stimulator of interferon genes (STING), thereby promoting paracrine senescence.

WebJul 12, 2024 · Indeed, fragmentation of NETs is required for cGAS activation in vitro, whereas digestion of their extranucleosomal DNA results in cGAS inactivation, suggesting that decompaction of chromatin exposing extranucleosomal DNA is required for cGAS activation in the cytosol. What other mechanisms for cGAS inhibition exist in the nucleus? incarnation\\u0027s csWebWe find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments in senescent cells. The activation of cGAS, in turn, triggers the production of … incarnation\\u0027s crWebNov 10, 2024 · Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer. Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the … incarnation\\u0027s cyWebHere, using NIH3T3 cells exposed to hydrogen peroxide stress, we show that stress-induced DNA damage provokes the SASP largely via cytosolic chromatin fragment (CCF) formation, which activates a cascade … in connection to github.com:443WebOct 28, 2024 · cytoplasmic chromatin fragment mitochondrial DNA retrotransposon senescence cancer aging Introduction DNA, in its function as the primary medium for storage of biological information, resides in specialized compartments, separate from the rest of the eukaryotic cell. in connection of thisWebDec 1, 2024 · Cytosolic short ssDNA molecules produced by end-resection processes during DSB repair have been reported to activate the IFN response in human breast … incarnation\\u0027s dfWebJul 31, 2024 · Cytosolic DNA fragments generated in senescent cells have been shown to stimulate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) … in connection with an arm an index is