Dichloromethane mutagenicity
WebThe mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast … WebMutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). ... Methanol (90%) and dichloromethane ...
Dichloromethane mutagenicity
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WebMutagenicity Genotoxicity in vivo - rat - Oral DNA damage Embryotoxicity Not Available Specific Target Organ Toxicity-single exposure ... Flammable liquids, toxic, n.o.s. (methanol and dichloromethane), 3, (6.1), pg II . Revised on 09/26/2024 Page 7 of 7 15. REGULATORY INFORMATION TSCA Inventory Status All ingredients are listed on the …
WebJan 1, 1978 · The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was … WebDichloromethane is a lipophilic solvent of low relative molecular mass, which can readily cross biological membranes. Pulmonary uptake is rapid, approaching steady state within …
WebMethylene Chloride is a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of … WebGerm cell mutagenicity No data available Carcinogenicity Evidence of a carcinogenic effect. IARC: 2A - Group 2A: Probably carcinogenic to humans (Dichloromethane) NTP: RAHC - Reasonably anticipated to be a human carcinogen (Dichloromethane) OSHA: OSHA specifically regulated carcinogen (Dichloromethane) Reproductive toxicity No …
WebBiodegradation of dichloromethane (DCM) to environmentally acceptable products was demonstrated under methanogenic conditions (35 degrees C). When DCM was supplied …
WebTheir mutagenicity was examined with Salmonella typhimurium TA98 in presence or absence of S9 mix. The total mutagenic activity of the acetone extract was 1.8-7.0-fold that of the dichloromethane extract. ... However, the amount of pyrene in the dichloromethane extract was much higher than in the acetone extract. These results indicate that the ... hamilton bijouxWebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - … hamilton c6 kostenWebThe results suggest that if an interaction between DCM and GSH is required for the activation of DCM to a bacterial mutagen, it occurs at low levels of endogenous GSH and is not significantly affected by GSH supplementation. Dichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a … hamilton county jail ohioWebMay 17, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are ... Osamu Endo, Kazuho Inaba, Yukari Totsuka, Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane, Mutagenesis, … pokemon immune to paralysisWebDichloromethane (DCM) is a colorless liquid with a sweet, pleasant odor. The major use of DCM is as a solvent in the pharmaceutical and chemical industry for reactions, purification and isolation of intermediates or products. pokemon hypno evolution lineWebfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This hamilton aviation museumWebDichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a bacterial mutagen. It has been suggested that the bacterial mutagenicity of DCM is mediated by glutathione (GSH) conjugation. The involvement of endogenous and exogenous GSH in the con … pokemon inteleon vmax