WebDec 17, 2024 · ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. The activation of STING1 … WebJun 29, 2024 · Acod1 mRNA is highly upregulated in splenic macrophages of V. Leishmania-infected mice, which aids parasite growth and survival. 32 ACOD1 may also contribute to …
Mitochondrial ACOD1/IRG1 in infection and sterile …
WebBy detecting the activation of glucose-6-phosphate dehydrogenase (G6PD), we confirmed that IRG1 could increase ROS level by promoting pentose phosphate pathway (PPP). DPI, … WebApr 1, 2024 · ACOD1 in sterile inflammatory diseases. In addition to pathogen infections, inflammation can also be triggered by tissue damage and stress, leading to various … nttr phone number
Itaconic acid induces ferroptosis by activating ferritinophagy
WebOct 29, 2024 · ACOD1 is a highly conserved gene that encodes an enzyme that catalyzes the decarboxylation of cis-aconitate to itaconic acid. Itaconic acid inhibits isocitrate lyase, a key enzyme of the glyoxylate shunt, a pathway essential for bacterial growth in macrophages ( Michelucci et al., 2013 ). Cloning and Expression WebJun 7, 2013 · Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more … WebTurboCHO™ High Throughput Services as fast as 2 weeks; TurboCHO™ Protein Expression in Singapore as fast as 8 BDs; TurboCHO™ Protein Expression Upgraded; MonoRab™ Rabbit mAb; Anti-idiotype Antibody Services New!; Neoantigen Peptide Service New! CRISPR sgRNA Services nttr land withdrawal