Lxrα-cyp7a1

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August undefined, 2024

Web20 mai 2012 · Inhibition of LXRα activity by the inhibitor GGPP abrogated the RSV-mediated upregulation of CYP7A1. These results suggest that LXRα-mediated transcriptional regulation is required for the induction of CYP7A1 by RSV. In summary, the present study demonstrated that dietary RSV increased CYP7A1 expression and bile acid pool size, … WebCompounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the antagonistic activity, we describe herein the synthesis, the pharmacological evaluation, and the in …

Stigmasterol stimulates transintestinal cholesterol excretion ...

Web30 nov. 2001 · CYP7A1 encodes the rate-limiting enzyme in the neutral bile acid biosynthetic pathway and is one of the principle means for eliminating cholesterol from the body. Mice lacking LXRα fail to increase production of CYP7A1 and exhibit profound liver accumulation of cholesterol esters ( 41 ). WebThe purpose of this study was to investigate whether persimmon tannin is associated with cholesterol efflux and macrophage-reverse cholesterol transport (RCT). chrome in play store

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WebDetermining association between genetic variations in Drug-Metabolizing Enzyme and Transporter genes and lipid-lowering response to a statin in hyperlipidemia http://manu43.magtech.com.cn/Jwk_sygzb/CN/10.3969/j.issn.1672-5069.2024.02.010 Web17 ian. 2012 · CYP7A1 encodes for the rate-limiting step in the conversion of cholesterol to bile acids in the liver. The inability of LXRα −/− mice to induce hepatic CYP7A1 expression results in a diminished ability to metabolize cholesterol to bile acids and the accumulation of cholesterol esters . In response to acute cholesterol feeding, CYP7A1 was ... chrome in pic

Transthyretin Regulated by linc00657/miR-205-5p ... - ScienceDirect

コレステロールの吸収および排出に関与する輸送たん白質の機能 …

WebWe characterize the ability of the liver X receptor (LXRα [NR1H3] and LXRβ [NR1H2]) agonist, T0901317, to activate the farnesoid X receptor (FXR [NR4H4]). Although T0901317 is a much more potent activator of LXR than FXR, this ligand actually activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid.Thus, the FXR … Web26 apr. 2002 · Dietary cholesterol stimulates CYP7A1 transcription via activation of oxysterol receptor, LXR alpha, whereas bile acids repress transcription through FXR-mediated … chrome in photoshopWeb15 mai 2013 · The major lipid-related target genes of PPARα are LPL and SREBP-2, while that of LXRα are CYP7A1, ABCA1, ABCG5 and ABCG8 (Reference Li and Glass 13, Reference Rakhshandehroo, Knoch and Muller 15, Reference Kalaany and Mangelsdorf 38). Hepatic LPL and PPARα mRNA expression were up-regulated by the C. oil treatment. chrome inprivate

"Web29 aug. 2024 · Surprisingly, contrary to this prediction, RXR agonist treatment decreases Cyp7a1 expression in both wild-type and LXRα-null mice . This finding led to the hypothesis that a distinct RXR heterodimeric partner might respond to bile acids, since bile acids have been known to induce feedback regulation in their synthesis by repressing Cyp7a1 ... " - Lxrα-cyp7a1

Lxrα-cyp7a1

Web动脉粥样硬化是常见慢性心脑血管疾病的病理基础,其病变始于血管内皮细胞构成的天然屏障功能障碍,由各种损伤因子影响 ... WebCholesterol 7α-hydroxylase (CYP7A1) encodes for the rate-limiting step in the conversion of cholesterol to bile acids in the liver. In response to acute cholesterol feeding, mice upregulate CYP7A1 via stimulation of the liver X receptor (LXR) α. However, the effect of a chronic high-cholesterol diet on hepatic CYP7A1 expression in mice is unknown. We …

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WebLXRα stimulates the transcription of mouse Cyp7a1, the rate-liming enzyme in the classical bile acid synthetic pathway. From: Vitamin D (Third Edition), 2011. ... (CYP7A1) is the … Web21 aug. 2013 · However, not all LXRα target genes were altered in miR-155 −/− livers, despite changes in LXRα expression (e.g. Cyp7a1 and Srebp1). We cannot exclude the possibility that these genes may be altered at other time points in the model and thus contribute to the observed phenotype. Furthermore, miRNAs are thought to be involved …

Web10 ian. 2001 · The cholesterol 7α-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol homeostasis.Oxysterol receptor, LXR, … Web摘要：目的探讨慢性乙型肝炎(chb)患者肝x受体α(lxrα)和细胞色素p450亚型7a1(cyp7a1)基因表达水平与肝组织病理学炎症和纤维化程度的关系。方法 2024年1月～2024年10月我院收治的chb患者118例,均接受肝穿刺活检,将炎症活动度分级＞g2和肝纤维化分期＞s2定义为肝组织炎症或纤维化程度显著;采用免疫组织 ...

Web13 mar. 2024 · C The protein levels of LXRα, CYP7A1 and CYP27A1. The column and its bar represented the means value and SE (n = 8), respectively. Significant difference is depicted as * P < 0.05 when compared with NBW-CON, # P < 0.05 when compared with IUGR-CON group. Web27 nov. 2024 · Additionally, Cyp7a1 knockout mice expressing human Cyp7a1 exhibit different responses to altered diets than wild-type counterparts . This discrepancy is likely due to the lack of an LXRα binding sequence in the promoter region of the human gene . BA composition can, therefore, be experimentally manipulated highlighting the potential ...

Web12 apr. 2012 · In mouse primary hepatocytes, cyanidin-3-O-β-glucoside treatment increased bile acid synthesis and CYP7A1 expression in a liver X receptor alpha (LXRα)-)-dependent manner. Scintillation proximity and time-resolved fluorescence resonance energy transfer assays revealed that cyanidin-3-O-β-glucoside functions as an agonist of LXRα. Conclusion chrome in privateWebRBP4, CYP17A1, CYP11A1, CYP7A1, CYP8B1, ABCB11, APOM, FAS Testicular orphan receptors* TR2/NR2C1; TR4/NR2C2 All major systems with peaks in the testis Negative modulators that suppress the transcriptional activity of other members of the NR superfamily NA ↑ POU5F1, NANOG, (TR2); ↑ POU5F1, NANOG, APOE, PCK2, CD36, LHCGR, … chrome input dateWeb1 mai 2002 · LXRα, which serves as a dominant CYP7A1 activator in the liver, exhibited a significant increase upon CA consumption (Fig. 5) and was also significantly correlated … chrome input colorWebる．そこで，LXRαにより同様に調節を受けるsterol regulatory element binding protein (SREBP)-1c，fatty acid synthase (FAS) および胆汁酸生合成の律速酵素であるcholesterol 7α-hydroxylase (CYP7A1) のmRNA発現量を測定した．FASmRNAはCAS群に比較し，SPI chrome inprivate windowWebConclusion: Our results indicate that the hypocholesterolemic activity of cyanidin-3-O-β-glucoside was, at least in part, mediated by activating the potential LXRα-CYP7A1-bile … chrome in private browserWebCholesterol mainly reverses transport into the liver by high-density lipoprotein (HDL); then, a third of them are converted into bile acid through the classical pathway (mainly by Cyp7a1 and Cyp8b1) or alternative pathways (mainly by Cyp27a1 and Cyp7b1). 6 Cholesterol transport is mediated by many membrane transporters, including ATP-binding ... chrome input fileWebIn this study, to clarify the role of IL-1 in the expression of the hepatic Cyp7a1 gene, we focused on Cyp7a1 transcriptional regulators such as α-fetoprotein transcription factor … chrome inprivateモード