Thiotepa route
WebThiotepa may be given rapidly intrave- nously in doses of 0.3–0.4 mg/kg at intervals of 1–4 weeks. The drug has also been given intra- venously in doses of 0.2 mg/kg or 6 mg/m2daily for 4 or 5 days at intervals of 2–4 weeks. Thiotepa has also been given intramuscularly in doses of 15–30 mg in various schedules. WebJul 16, 2024 · Thiotepa can be given in several ways, including: into a vein (intravenous), into the bladder (intravesicular), into the spinal fluid (intrathecal), and into the abdominal cavity (intraperitoneal). The dose is dependent on your size, the method of administration, and the type of cancer being treated.
Thiotepa route
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WebApr 1, 2024 · Thiotepa belongs to the group of medicines called alkylating agents. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by thiotepa, other effects will also occur. Some of these may be serious and must be reported to your doctor. WebRoute & Dosage Malignant Lymphomas Adult: IV 0.3–0.4 mg/kg q1–4wk Intratumor 0.6–0.8 mg/kg directly into tumor q1–4wk Intracavitary 0.6–0.8 mg/kg instilled through same tubing used for paracentesis at intervals of at least 1 wk Intravesicular 60 mg in 30–60 mL of distilled water instilled into bladder to be retained for 2 h once/wk ...
WebApr 1, 2024 · Thiotepa (Injection Route) Side Effects Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects … WebThis will help prevent kidney problems and keep your kidneys working well. Thiotepa sometimes causes nausea, vomiting, and loss of appetite. However, it is very important …
WebThiotepa (also known as Thioplex ®) is an anticancer medicine. It is a clear liquid given by vein (IV). Thiotepa can pose a health hazard to caregivers. All caregivers should take safety precautions while giving this drug. For 48 hours after this drug is given, the patient’s body fluids can contain the drug. WebOct 15, 2024 · Thiotepa can cause fetal harm when administered to a pregnant woman. Thiotepa given by the IP route was teratogenic in mice at doses ≥ 1 mg/kg (3.2 mg/m2), approximately 8-fold less than the maximum recommended human therapeutic dose based on body-surface area.
Webprecautions should be followed when handling thiotepa; if skin contact occurs, wash the area thoroughly with soap and water; if mucous membrane contact occurs, flush thoroughly with water. 2. Carcinogenicity: Thiotepa is carcinogenic. 2. Mutagenicity: Mutagenic in Ames test and mammalian in vitro mutation test. 2 Thiotepa is clastogenic in ...
WebSep 6, 2024 · Thiotepa given by the IP route was teratogenic in rats at doses ≥ 3 mg/kg (21 mg/m2), approximately equal to the maximum recommended human therapeutic dose, … prince georges county efilingWebDec 5, 2024 · Thiotepa given by the IP route was teratogenic in rats at doses ≥ 3 mg/kg (21 mg/m 2), approximately equal to the maximum recommended human therapeutic dose, based on body-surface area. Thiotepa was lethal to rabbit fetuses at a dose of 3 mg/kg (41 mg/m 2 ), approximately two times the maximum recommended human therapeutic dose … prince georges county employee relationsWebLength: 36 mile loop. Driving time: 1 hour. Getting there: Shoshone, just south of the intersection of Highways 127 and 178 east of Death Valley National Park, is the beginning … prince georges county emergency servicesWebThiotepa is approved to treat: Bladder cancer. Breast cancer. Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Ovarian cancer. Thiotepa is also being studied in the treatment of other types of cancer and as part of a regimen to prepare patients for bone marrow and stem cell transplants. prince georges county eplansWebThiotepa (Tepadina) Thiotepa is a chemotherapy drug. It is mainly used to prepare people for a bone marrow transplant. How does thiotepa work? Thiotepa is a type of drug called an alkylating agent. It works by sticking to 1 of the cancer cell's DNA strands. Then the cell can't divide into 2 new cells. prince georges county epaymentWebSep 12, 2024 · Thiotepa is an intravenously or locally applied alkylating agent which is currently used in the therapy of breast, ovarian and bladder cancer. Thiotepa therapy has been associated with low rates of serum … prince georges county emergencyWebFeb 16, 2024 · Thiotepa Riemser is indicated, in combination with other chemotherapy medicinal products: with or without total body irradiation (TBI), as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients; pleasant ridge park map